def is_endwith_s(n):
    """
    判断是否以s结尾
    :param n: str or int
    :return: bool
    """
    return str(n).endswith('s')

# 待判断的可迭代对象
lis = ['ss', 'ss', 'ss', 'aa', 'aa', 'ss', 'ss', 'ss', 'ss', '22']

lis_s = [word if is_endwith_s(word) else '666' for word in lis]

print(lis_s)

# ['ss', 'ss', 'ss', '666', '666', 'ss', 'ss', 'ss', 'ss', '666']